Named for the Skip James song "22-20 Blues," the 22-20s hail from Lincolnshire, England, and mix blues, rock, folk, and country influences into a sound that got the quartet noticed early in its career. Vocalist/guitarist Martin Trimble and bassist Glen Bartup had played together in local bands for several years, but formed the 22-20s in mid-2002, while they were still both in their early twenties. Keyboardist Charly Coombes and a series of drummers rounded out the band's initial lineup before the band settled on James Irving as their permanent drummer. The group's consistent gigging caught the ears of Heavenly Records, which signed the band late in 2002; early the following year, the 22-20s released their first single, Such a Fool, as a limited-edition 7". Soon after, they made their first U.S. appearance at the 2003 Coachella Festival; during their U.K. tour later that spring, they also recorded the 05-03 EP, which previewed a handful of their songs in concert.
The band originally disbanded in December 2005 before reforming in 2008 and releasing Shake/Shiver/Moan in 2010 and Got It If You Want It in 2012. They disbanded for a second time in early 2013, before reforming again in late 2019.